It directly or indirectly regulates anywhere from 200 (known) to 2,700 genes (VDR present) on the active human genome. It works through regulation of the steroid hormone/thyroid hormone class of super-receptors. Clinicians should discuss the service with eligible patients.” (USPTF)ħ The Use of Vitamin D in Clinical Practiceīefore we look at current RCTs, keep in mind: Activated vitamin D is a seco-steroid hormone. Level A recommendations: “Good scientific evidence suggests that the benefits of the clinical service substantially outweigh the potential risks.
“Level I evidence is evidence obtained from at least one properly designed randomized controlled trial.” (US Preventive Services Task Force or USPTF).
What kind of studies have been done for vitamin D? Lots of cross-sectional and case-control studies Some prospective cohort studies Phase IIb randomized controlled trials are just now pouring out These trials are demonstrating that vitamin D can be used to treat or aid traditional therapies for a wide array of diseases.Ħ The Use of Vitamin D in Clinical Practice Eur J Nutr, 2012.ĥ The Use of Vitamin D in Clinical Practice Vitamin D status indicators in indigenous populations in East Africa. This means doses of up to 10,000 IU/day are safe (probably much higher). For now, fair to presume that these are the levels humans should have CDC reported average American has a level of 22 ng/ml Serum levels up to 100 ng/ml are safe. What do we know about vitamin D? We live in a sun-deprived developed world Common sense says vitamin D-deprived world, too Hunter-gatherers have 25(OH)D levels of around 45 ng/ml. However, doctors have always been ethically and legally obligated to act on what is currently known.Ĥ The Use of Vitamin D in Clinical Practice Phase III large randomized controlled trials have not been done for vitamin D supplementation. I have a book out on athletic performance and vitamin D, entitled Athletes Edge, Faster, Quicker, Stronger with vitamin D, but I don’t have any copies with me.ģ The Use of Vitamin D in Clinical Practice I receive royalties from Purity Products for a vitamin D formula with my name and likeness on it, but I don’t have any of it with me). John J Cannell, MD Executive Director, Vitamin D CouncilĢ The Use of Vitamin D in Clinical Practiceĭisclosures I am paid a salary as the Executive Director of the Vitamin D Council, a 501(c)(3) non-profit. 1 The Use of Vitamin D in Clinical Practice
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